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IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure

21 Oct 2015

Abstract excerpt

Interferon gamma (IFN-γ) has been reported to have both negative and positive activity on hematopoietic cells, adding complexity to the interpretation of its pleiotropic functions. We examined the effects of IFN-γ on murine hematopoietic stem cells (HSCs) and progenitors in vitro and in vivo by using mouse models. IFN-γ treatment expanded bone marrow (BM) c-Kit(+)Sca1(+)Lin(-) (KSL) cell number but reduced BM...

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PMID: 26491068
DOI: 10.1182/blood-2015-06-652453

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