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Article

Hematopoietic stem cell loss and hematopoietic failure in severe aplastic anemia is driven by macrophages and aberrant podoplanin expression.

Haematologica - 1 Sept 2018

McCabe Amanda, Smith Julianne N P, Costello Angelica, Maloney Jackson, Katikaneni Divya, MacNamara Katherine C

Abstract excerpt

Severe aplastic anemia (SAA) results from profound hematopoietic stem cell loss. T cells and interferon gamma (IFNγ) have long been associated with SAA, yet the underlying mechanisms driving hematopoietic stem cell loss remain unknown. Using a mouse model of SAA, we demonstrate that IFNγ-dependent hematopoietic stem cell loss required macrophages. IFNγ was necessary for bone marrow macrophage persistence, despite...

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Identifiers

PMID: 29773597
DOI: 10.3324/haematol.2018.189449
PMCID: PMC6119154

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