IFN-γ Negatively Modulates Self-Renewal of Repopulating Human Hemopoietic Stem Cells

doi:10.4049/jimmunol.174.2.752

Article

IFN-γ Negatively Modulates Self-Renewal of Repopulating Human Hemopoietic Stem Cells

1 Jan 2005

Abstract excerpt

Whereas multiple growth-promoting cytokines have been demonstrated to be involved in regulation of the hemopoietic stem cell (HSC) pool, the potential role of negative regulators is less clear. However, IFN-gamma, if overexpressed, can mediate bone marrow suppression and has been directly implicated in a number of bone marrow failure syndromes, including graft-vs-host disease. Whether IFN-gamma might directly...

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