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Article

IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2015

Metidji Amina, Rieder Sadiye Amcaoglu, Glass Deborah Dacek, Cremer Isabelle, Punkosdy George A, Shevach Ethan M

Abstract excerpt

Type I IFNs are a family of cytokines with antiviral and immunomodulatory properties. Although the antiviral effects of IFNs are well characterized, their immunomodulatory properties are less clear. To specifically address the effects of type I IFNs on T regulatory cells (Tregs), we studied mixed bone marrow chimeras between wild-type and IFN-α/β receptor (IFNAR) knockout (KO) mice, and heterozygous female mice...

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Identifiers

PMID: 25795758
DOI: 10.4049/jimmunol.1500036
PMCID: PMC4402260

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