Article
Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome.
Circulation research - 7 Jan 2022
Zanoni Paolo, Panteloglou Grigorios, Othman Alaa, Haas Joel T, Meier Roger, Rimbert Antoine, Futema Marta, Abou Khalil Yara, Norrelykke Simon F, Rzepiela Andrzej J, Stoma Szymon, Stebler Michael, van Dijk Freerk, Wijers Melinde, Wolters Justina C, Dalila Nawar, Huijkman Nicolette C A, Smit Marieke, Gallo Antonio, Carreau Valérie, Philippi Anne, Rabès Jean-Pierre, Boileau Catherine, Visentin Michele, Vonghia Luisa, Weyler Jonas, Francque Sven, Verrijken An, Verhaegen Ann, Van Gaal Luc, van der Graaf Adriaan, van Rosmalen Belle V, Robert Jerome, Velagapudi Srividya, Yalcinkaya Mustafa, Keel Michaela, Radosavljevic Silvija, Geier Andreas, Tybjaerg-Hansen Anne, Varret Mathilde, Rohrer Lucia, Humphries Steve E, Staels Bart, van de Sluis Bart, Kuivenhoven Jan Albert, von Eckardstein Arnold
Abstract excerpt
BACKGROUND: The LDLR (low-density lipoprotein receptor) in the liver is the major determinant of LDL-cholesterol levels in human plasma. The discovery of genes that regulate the activity of LDLR helps to identify pathomechanisms of hypercholesterolemia and novel therapeutic targets against atherosclerotic cardiovascular disease. METHODS: We performed a genome-wide RNA interference screen for genes limiting the...
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