Article
Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression.
Diabetes - 1 Feb 2016
Traurig Michael, Hanson Robert L, Marinelarena Alejandra, Kobes Sayuko, Piaggi Paolo, Cole Shelley, Curran Joanne E, Blangero John, Göring Harald, Kumar Satish, Nelson Robert G, Howard Barbara V, Knowler William C, Baier Leslie J, Bogardus Clifton
Abstract excerpt
Genetic variants in SLC16A11 were recently reported to be associated with type 2 diabetes in Mexican and other Latin American populations. The diabetes risk haplotype had a frequency of 50% in Native Americans from Mexico but was rare in Europeans and Africans. In the current study, we analyzed SLC16A11 in 12,811 North American Indians and found that the diabetes risk haplotype, tagged by the rs75493593 A allele,...
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