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Article

SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.

Molecular genetics and metabolism - 1 Dec 2011

Dong Yan, Guo Tingwei, Traurig Michael, Mason Clint C, Kobes Sayuko, Perez Jessica, Knowler William C, Bogardus Clifton, Hanson Robert L, Baier Leslie J

Abstract excerpt

Genetic variation in SIRT1 affects obesity-related phenotypes in several populations. The purpose of this study was to determine whether variation in SIRT1 affects susceptibility to obesity or type 2 diabetes in Pima Indians, a population with very high prevalence and incidence rates of these diseases. Genotypic data from single nucleotide polymorphisms (SNPs) identified by sequencing regions of SIRT1 combined...

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Identifiers

PMID: 21871827
DOI: 10.1016/j.ymgme.2011.08.001
PMCID: PMC3224181

Genes

SIRT1

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Related research

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SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.PMID 21871827Read ↗

Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion.Semantic proximity Read ↗

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Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.Semantic proximity Read ↗

Identification of a SIRT1 mutation in a family with type 1 diabetes.Semantic proximity Read ↗

11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle.Semantic proximity Read ↗

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