Article
Trade-Offs of Escherichia coli Adaptation to an Intracellular Lifestyle in Macrophages.
PloS one - 1 Jan 2016
Azevedo M, Sousa A, Moura de Sousa J, Thompson J A, Proença J T, Gordo I
Abstract excerpt
The bacterium Escherichia coli exhibits remarkable genomic and phenotypic variation, with some pathogenic strains having evolved to survive and even replicate in the harsh intra-macrophage environment. The rate and effects of mutations that can cause pathoadaptation are key determinants of the pace at which E. coli can colonize such niches and become pathogenic. We used experimental evolution to determine the...
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