Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin Signaling

20 Oct 2015

Abstract excerpt

Merlin, the protein encoded by the NF2 gene, is a member of the band 4.1 family of cytoskeleton-associated proteins and functions as a tumor suppressor for many types of cancer. However, the roles and mechanism of Merlin expression in pancreatic cancer have remained unclear. In this study, we sought to determine the impact of Merlin expression on pancreatic cancer development and progression using human tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apelin-related biomedical research
Share to Axon Guidance and Neuronal Signaling
Share to FOXO transcription factor regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26483206
DOI: 10.1158/0008-5472.can-14-1952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin SignalingPMID 26483206Read ↗

Merlin regulates signaling events at the nexus of development and cancerSemantic proximity Read ↗

The molecular biology of NF2/Merlin on tumorigenesis and development.Semantic proximity Read ↗

Merlin is a potent inhibitor of glioma growth.Semantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression.Semantic proximity Read ↗

TFCP2 activates beta-catenin/TCF signaling in the progression of pancreatic cancerSemantic proximity Read ↗

FAT10 promotes chemotherapeutic resistance in pancreatic cancer by inducing epithelial-mesenchymal transition via stabilization of FOXM1 expressionSemantic proximity Read ↗

Shedding light on Merlin's wizardry.Semantic proximity Read ↗

MSI2 regulates NLK-mediated EMT and PI3K/AKT/mTOR pathway to promote pancreatic cancer progressionSemantic proximity Read ↗

Protein 4.1 tumor suppressors: getting a FERM grip on growth regulationSemantic proximity Read ↗

SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-αSemantic proximity Read ↗

Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.