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Article

Merlin regulates signaling events at the nexus of development and cancer

16 Apr 2020

Abstract excerpt

BACKGROUND: In this review, we describe how the cytoskeletal protein Merlin, encoded by the Neurofibromin 2 (NF2) gene, orchestrates developmental signaling to ensure normal ontogeny, and we discuss how Merlin deficiency leads to aberrant activation of developmental pathways that enable tumor development and malignant progression. MAIN BODY: Parallels between embryonic development and cancer have underscored the...

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PMID: 32299434
DOI: 10.1186/s12964-020-00544-7

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