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Article

Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice.

Scientific reports - 20 Oct 2015

Shih Yao-Ming, Sun Cheng-Pu, Chou Hui-Hsien, Wu Tzu-Hui, Chen Chun-Chi, Wu Ping-Yi, Enya Chen Yu-Chen, Bissig Karl-Dimiter, Tao Mi-Hua

Abstract excerpt

Selection of escape mutants with mutations within the target sequence could abolish the antiviral RNA interference activity. Here, we investigated the impact of a pre-existing shRNA-resistant HBV variant on the efficacy of shRNA therapy. We previously identified a highly potent shRNA, S1, which, when delivered by an adeno-associated viral vector, effectively inhibits HBV replication in HBV transgenic mice. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hepatitis B, Chronic

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Source

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Identifiers

PMID: 26482836
DOI: 10.1038/srep15259
PMCID: PMC4612501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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