Article
Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2013
Wooddell Christine I, Rozema David B, Hossbach Markus, John Matthias, Hamilton Holly L, Chu Qili, Hegge Julia O, Klein Jason J, Wakefield Darren H, Oropeza Claudia E, Deckert Jochen, Roehl Ingo, Jahn-Hofmann Kerstin, Hadwiger Philipp, Vornlocher Hans-Peter, McLachlan Alan, Lewis David L
Abstract excerpt
RNA interference (RNAi)-based therapeutics have the potential to treat chronic hepatitis B virus (HBV) infection in a fundamentally different manner than current therapies. Using RNAi, it is possible to knock down expression of viral RNAs including the pregenomic RNA from which the replicative intermediates are derived, thus reducing viral load, and the viral proteins that result in disease and impact the immune...
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