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Article

Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells.

Journal of autoimmunity - 1 Feb 2016

Rattay Kristin, Meyer Hannah Verena, Herrmann Carl, Brors Benedikt, Kyewski Bruno

Abstract excerpt

Promiscuous expression of a plethora of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for central tolerance. This promiscuous gene expression (pGE) is characterized by inclusion of a broad range of TRAs and by its mosaic expression patterns, i.e. each antigen is only expressed in 1-3% of mTECs. It is currently unclear to which extent random and/or deterministic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26481130
DOI: 10.1016/j.jaut.2015.10.001

Genes

TRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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