Article
The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.
Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2008
Venanzi Emily S, Melamed Rachel, Mathis Diane, Benoist Christophe
Abstract excerpt
The Aire transcription factor plays an important role in immunological self-tolerance by mediating the ectopic expression of peripheral self-antigens by thymic medullary epithelial cells (MECs), and the deletion of thymocytes that recognize them. In Aire-deficient humans or mice, central tolerance is incomplete and multiorgan autoimmune disease results. We examined the variability of Aire's effects on ectopic...
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