Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2008

Venanzi Emily S, Melamed Rachel, Mathis Diane, Benoist Christophe

Abstract excerpt

The Aire transcription factor plays an important role in immunological self-tolerance by mediating the ectopic expression of peripheral self-antigens by thymic medullary epithelial cells (MECs), and the deletion of thymocytes that recognize them. In Aire-deficient humans or mice, central toleranc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIRE Protein
Share to Autoantigens
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Mice, Inbred Strains

Share to Self Tolerance

Share to Thymus Gland

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 18838677
DOI: 10.1073/pnas.0808070105
PMCID: PMC2572942

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18838677-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.PMID 18838677Read ↗

AIRE expands: new roles in immune tolerance and beyond.Semantic proximity Read ↗

Aire in Autoimmunity.Semantic proximity Read ↗

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.Semantic proximity Read ↗

AireSemantic proximity Read ↗

AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression*Semantic proximity Read ↗

Aire-dependent transcripts escape Raver2-induced splice-event inclusion in the thymic epithelium.Semantic proximity Read ↗

Twenty Years of AIRESemantic proximity Read ↗

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient MiceSemantic proximity Read ↗

Update on Aire and thymic negative selection.Semantic proximity Read ↗

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.Semantic proximity Read ↗

Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells.Semantic proximity Read ↗

Disruption of immunological tolerance: role of AIRE gene in autoimmunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.