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Article

Capsid and Genome Modification Strategies to Reduce the Immunogenicity of Adenoviral Vectors

28 Feb 2021

Abstract excerpt

Adenovirus-based gene transfer vectors are the most frequently used vector type in gene therapy clinical trials to date, and they play an important role as genetic vaccine candidates during the ongoing SARS-CoV-2 pandemic. Immediately upon delivery, adenovirus-based vectors exhibit multiple complex vector-host interactions and induce innate and adaptive immune responses. This can severely limit their safety and...

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PMID: 33670859
DOI: 10.3390/ijms22052417

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