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Simian Adenoviruses As Vaccine Vectors

1 Sept 2016

Abstract excerpt

Replication incompetent human adenovirus serotype 5 (HAdV-C5) has been extensively used as a delivery vehicle for gene therapy proteins and infectious disease antigens. These vectors infect replicating and nonreplicating cells, have a broad tissue tropism, elicit high immune responses and are easily purified to high titers. However, the utility of HAdV-C5 vectors as potential vaccines is limited due to...

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PMID: 29527232
DOI: 10.2217/fvl-2016-0070

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