Article
A common risk variant in CACNA1C supports a sex-dependent effect on longitudinal functioning and functional recovery from episodes of schizophrenia-spectrum but not bipolar disorder.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Dec 2015
Heilbronner Urs, Malzahn Dörthe, Strohmaier Jana, Maier Sandra, Frank Josef, Treutlein Jens, Mühleisen Thomas W, Forstner Andreas J, Witt Stephanie H, Cichon Sven, Falkai Peter, Nöthen Markus M, Rietschel Marcella, Schulze Thomas G
Abstract excerpt
Sex is a powerful modulator of disease susceptibility, course and outcome. The gene CACNA1C is among the best replicated vulnerability genes of bipolar disorder and schizophrenia. The aim of the present study was to investigate whether sex and a variant in CACNA1C (rs10774035 as a proxy for the well-acknowledged risk variant rs1006737) influence psychosocial adaptation in a large German patient sample with...
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