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Article

BDNF Levels According to Variations in the CACNA1C Gene: Sex-Based Disparity.

Cellular and molecular neurobiology - 1 Jan 2023

Bastos Clarissa Ribeiro, Xavier Janaina, Camerini Laísa, Dewes Samantha Seibt, Moreira Fernanda Pedrotti, Wiener Carolina David, Jansen Karen, Kaster Manuella Pinto, de Mattos Souza Luciano Dias, da Silva Ricardo Azevedo, Oses Jean Pierre, Portela Luis Valmor, Lara Diogo Rizzato, Tovo-Rodrigues Luciana, Ghisleni Gabriele

Abstract excerpt

The CACNA1C gene encodes the pore-forming alpha-1c subunit of L-type voltage-gated calcium channels. The calcium influx through these channels regulates the transcription of the brain-derived neurotrophic factor (BDNF). Polymorphisms in this gene have been consistently associated with psychiatric disorders, and alterations in BDNF levels are a possible biological mechanism to explain such associations. Here, we...

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Identifiers

PMID: 35128618
DOI: 10.1007/s10571-022-01189-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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