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Article

Greatly increased numbers of histamine cells in human narcolepsy with cataplexy.

Annals of neurology - 1 Dec 2013

John Joshi, Thannickal Thomas C, McGregor Ronald, Ramanathan Lalini, Ohtsu Hiroshi, Nishino Seiji, Sakai Noriaki, Yamanaka Akhiro, Stone Carly, Cornford Marcia, Siegel Jerome M

Abstract excerpt

OBJECTIVE: To determine whether histamine cells are altered in human narcolepsy with cataplexy and in animal models of this disease. METHODS: Immunohistochemistry for histidine decarboxylase (HDC) and quantitative microscopy were used to detect histamine cells in human narcoleptics, hypocretin (Hcrt) receptor-2 mutant dogs, and 3 mouse narcolepsy models: Hcrt (orexin) knockouts, ataxin-3-orexin, and...

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Source

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Identifiers

PMID: 23821583
DOI: 10.1002/ana.23968
PMCID: PMC8211429

Genes

HDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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