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Article

Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation.

Oncotarget - 10 Nov 2015

Jang Yunseon, Han Jeongsu, Kim Soo Jeong, Kim Jungim, Lee Min Joung, Jeong Soyeon, Ryu Min Jeong, Seo Kang-Sik, Choi Song-Yi, Shong Minho, Lim Kyu, Heo Jun Young, Kweon Gi Ryang

Abstract excerpt

Renal cell carcinoma (RCC) progression resulting from the uncontrolled migration and enhanced angiogenesis is an obstacle to effective therapeutic intervention. Tumor metabolism has distinctive feature called Warburg effect, which enhances the aerobic glycolysis rapidly supplying the energy for migration of tumor. To manipulate this metabolic change characteristic of aggressive tumors, we utilized the citrus...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26474388
DOI: 10.18632/oncotarget.5511
PMCID: PMC4741988

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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