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Article

2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma.

Carcinogenesis - 1 Apr 2011

Nagaprashantha Lokesh Dalasanur, Vatsyayan Rit, Singhal Jyotsana, Lelsani Poorna, Prokai Laszlo, Awasthi Sanjay, Singhal Sharad S

Abstract excerpt

Renal cell carcinoma (RCC) is one of the top ten cancers prevalent in USA. Loss-of-function mutations in the von Hippel-Lindau (VHL) gene constitute an established risk factor contributing to 75% of total reported cases of RCC. Loss-of-VHL leads to a highly vascularized phenotype of renal tumors. Intake of citrus fruits has been proven to reduce the risk of RCC in multicenter international studies. Hence, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 21304051
DOI: 10.1093/carcin/bgr021
PMCID: PMC3066423

Genes

VHL
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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