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Article

Adenylate kinase-4 modulates oxidative stress and stabilizes HIF-1α to drive lung cancer metastasis

2017-10-01

Abstract excerpt

Disrupting signaling axes that are essential for tumor metastasis may provide therapeutic opportunity to cure cancer. We previously identified adenylate kinase 4 (AK4) as a biomarker of metastasis in lung cancer. Here we analyze AK4-associated metabolic gene signature and reveal HIF-1α is transcriptionally activated and associated with poor prognosis in lung adenocarcinoma patients. Overexpression of AK4 shifts me...

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Literature Corpus work
f37438ae-7649-598d-80e2-0e9f06095203
DOI
10.1101/196857
Open publication

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Adenylate kinase-4 modulates oxidative stress and stabilizes HIF-1α to drive lung cancer metastasisDOI 10.1101/196857
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