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Article

BMP9 is a key player in endothelial identity and its loss is sufficient to induce arteriovenous malformations.

Cardiovascular research - 29 May 2024

Desroches-Castan Agnes, Koca Dzenis, Liu Hequn, Roelants Caroline, Resmini Léa, Ricard Nicolas, Bouvard Claire, Chaumontel Nicolas, Tharaux Pierre-Louis, Tillet Emmanuelle, Battail Christophe, Lenoir Olivia, Bailly Sabine

Abstract excerpt

AIMS: BMP9 is a high affinity ligand of ALK1 and endoglin receptors that are mutated in the rare genetic vascular disorder hereditary hemorrhagic telangiectasia (HHT). We have previously shown that loss of Bmp9 in the 129/Ola genetic background leads to spontaneous liver fibrosis via capillarization of liver sinusoidal endothelial cells (LSEC) and kidney lesions. We aimed to decipher the molecular mechanisms...

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Identifiers

PMID: 38502919
DOI: 10.1093/cvr/cvae052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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