Article
The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.
Nature communications - 15 Oct 2015
Nakasaki Manando, Hwang Yongsung, Xie Yun, Kataria Sunny, Gund Rupali, Hajam Edries Y, Samuel Rekha, George Renu, Danda Debashish, M J Paul, Nakamura Tomoyuki, Shen Zhouxin, Briggs Steve, Varghese Shyni, Jamora Colin
Abstract excerpt
Fibrosis is a pervasive disease in which the excessive deposition of extracellular matrix (ECM) compromises tissue function. Although the underlying mechanisms are mostly unknown, matrix stiffness is increasingly appreciated as a contributor to fibrosis rather than merely a manifestation of the disease. Here we show that the loss of Fibulin-5, an elastic fibre component, not only decreases tissue stiffness, but...
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