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Article

The MicroRNA miR-155 Is Essential in Fibrosis

12 Mar 2019

Abstract excerpt

The function of microRNAs (miRNAs) during fibrosis and the downstream regulation of gene expression by these miRNAs have become of great biological interest. miR-155 is consistently upregulated in fibrotic disorders, and its ablation downregulates collagen synthesis. Studies demonstrate the integral role of miR-155 in fibrosis, as it mediates TGF-β1 signaling to drive collagen synthesis. In this review, we...

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PMID: 30871125
DOI: 10.3390/ncrna5010023

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