Article
Comparison of 454 Ultra-Deep Sequencing and Allele-Specific Real-Time PCR with Regard to the Detection of Emerging Drug-Resistant Minor HIV-1 Variants after Antiretroviral Prophylaxis for Vertical Transmission.
PloS one - 1 Jan 2015
Hauser Andrea, Kuecherer Claudia, Kunz Andrea, Dabrowski Piotr Wojtek, Radonić Aleksandar, Nitsche Andreas, Theuring Stefanie, Bannert Norbert, Sewangi Julius, Mbezi Paulina, Dugange Festo, Harms Gundel, Meixenberger Karolin
Abstract excerpt
BACKGROUND: Pregnant HIV-infected women were screened for the development of HIV-1 drug resistance after implementation of a triple-antiretroviral transmission prophylaxis as recommended by the WHO in 2006. The study offered the opportunity to compare amplicon-based 454 ultra-deep sequencing (UDS) and allele-specific real-time PCR (ASPCR) for the detection of drug-resistant minor variants in the HIV-1 reverse...
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