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Article

Ultrasensitive detection of minor drug-resistant variants for HIV after nevirapine exposure using allele-specific PCR: clinical significance.

AIDS research and human retroviruses - 1 Mar 2010

Rowley Christopher F, Boutwell Christian L, Lee Esther J, MacLeod Iain J, Ribaudo Heather J, Essex M, Lockman Shahin

Abstract excerpt

HIV-1 drug resistance mutations have been detected at low frequencies after single-dose nevirapine (sdNVP) for prevention of mother-to-child transmission (PMTCT). We investigated the relationship between these "minor variant" NVP-resistant viruses and clinical outcome with NVP-containing antiretroviral therapy (ART). An allele-specific quantitative PCR (ASPCR) assay was used to quantify the pre-ART frequency of...

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Identifiers

PMID: 20334564
DOI: 10.1089/aid.2009.0082
PMCID: PMC2864062

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