Article
Characterization of HIV drug resistance mutations among patients failing first-line antiretroviral therapy from a tertiary referral center in Lusaka, Zambia.
Journal of medical virology - 1 Jul 2015
Seu Lillian, Mulenga Lloyd B, Siwingwa Mpanji, Sikazwe Izukanji, Lambwe Nason, Guffey M Bradford, Chi Benjamin H
Abstract excerpt
In settings of resource constraint, an understanding of HIV drug resistance can guide antiretroviral therapy (ART) at switch to second-line therapy. To determine the prevalence of such HIV drug resistance mutations (HIV DRM), we used an in-house sequencing assay in the pol gene (protease and partial reverse transcriptase) in a cohort of patients suspected of failing a first-line regimen, which in Zambia comprises...
Topics
- Adult
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- Drug Resistance, Viral
- Female
- Genotype
- HIV Infections
- HIV Protease
- HIV-1
- Humans
- Male