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Article

An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma.

PloS one - 1 Jan 2015

Sawada Genta, Niida Atsushi, Hirata Hidenari, Komatsu Hisateru, Uchi Ryutaro, Shimamura Teppei, Takahashi Yusuke, Kurashige Junji, Matsumura Tae, Ueo Hiroki, Takano Yuki, Ueda Masami, Sakimura Shotaro, Shinden Yoshiaki, Eguchi Hidetoshi, Sudo Tomoya, Sugimachi Keishi, Yamasaki Makoto, Tanaka Fumiaki, Tachimori Yuji, Kajiyama Yoshiaki, Natsugoe Shoji, Fujita Hiromasa, Tanaka Yoichi, Calin George, Miyano Satoru, Doki Yuichiro, Mori Masaki, Mimori Koshi

Abstract excerpt

BACKGROUND: Few driver genes have been well established in esophageal squamous cell carcinoma (ESCC). Identification of the genomic aberrations that contribute to changes in gene expression profiles can be used to predict driver genes. METHODS: We searched for driver genes in ESCC by integrative analysis of gene expression microarray profiles and copy number data. To narrow down candidate genes, we performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26465158
DOI: 10.1371/journal.pone.0139808
PMCID: PMC4605796

Genes

GRB7
ERBB2
CCND1
EGFR
SOX2

Provenance

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