Article
Phosphodiesterase 1 regulation is a key mechanism in vascular aging.
Clinical science (London, England : 1979) - 1 Dec 2015
Bautista Niño Paula K, Durik Matej, Danser A H Jan, de Vries René, Musterd-Bhaggoe Usha M, Meima Marcel E, Kavousi Maryam, Ghanbari Mohsen, Hoeijmakers Jan H, O'Donnell Christopher J, Franceschini Nora, Janssen Ger M J, De Mey Jo G R, Liu Yiwen, Shanahan Catherine M, Franco Oscar H, Dehghan Abbas, Roks Anton J M
Abstract excerpt
Reduced nitric oxide (NO)/cGMP signalling is observed in age-related vascular disease. We hypothesize that this disturbed signalling involves effects of genomic instability, a primary causal factor in aging, on vascular smooth muscle cells (VSMCs) and that the underlying mechanism plays a role in human age-related vascular disease. To test our hypothesis, we combined experiments in mice with genomic instability...
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