Article
Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS-STING Pathway and Reverses Macrophage-Like VSMC Phenotypes in Progeroid DNA-Repair-Deficient Ercc1Δ /- Mice.
Aging cell - 1 Jul 2025
Stefens S J M, van der Linden J, Heredia-Genestar J M, Brandt R M C, Barnhoorn S, Nieuwenhuizen-Bakker I, van Vliet N, Odijk J H M, Ridwan Y, Stuijts D, Batenburg M, Hoeijmakers J H J, Kanaar R, Essers J, van der Pluijm I
Abstract excerpt
Aging is a major risk factor for cardiovascular diseases, and the accumulation of DNA damage significantly contributes to the aging process. This study aimed to identify the underlying molecular mechanisms of vascular aging in DNA-repair-deficient progeroid Ercc1Δ/- mice and to explore the therapeutic effect of dietary restriction (DR). RNA sequencing analysis revealed that DR reversed gene expression of vascular...
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