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Article

Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites.

Nucleic acids research - 18 Feb 2016

Lee Seung-Tae, Wiemels Joseph L

Abstract excerpt

The epigenetic landscape of cancer includes both focal hypermethylation and broader hypomethylation in a genome-wide manner. By means of a comprehensive genomic analysis on 6637 tissues of 21 tumor types, we here show that the degrees of overall methylation in CpG island (CGI) and demethylation in intergenic regions, defined as 'backbone', largely vary among different tumors. Depending on tumor type, both CGI...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26464434
DOI: 10.1093/nar/gkv1038
PMCID: PMC4756811

Genes

IDH1
NSD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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