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A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers

1 Sept 2018

Abstract excerpt

Cancer progression to an aggressive phenotype often co-opts aspects of stem cell biology. Here, we developed gene signatures for normal human stem cell populations to understand the relationship between epithelial cancers and stem cell transcriptional programs. Using a pan-cancer approach, we reveal that aggressive epithelial cancers are enriched for a transcriptional signature shared by epithelial adult stem...

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PMID: 30232014
DOI: 10.1016/j.celrep.2018.08.062

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