Article
Lineage relationship of prostate cancer cell types based on gene expression.
BMC medical genomics - 23 May 2011
Pascal Laura E, Vêncio Ricardo Zn, Vessella Robert L, Ware Carol B, Vêncio Eneida F, Denyer Gareth, Liu Alvin Y
Abstract excerpt
BACKGROUND: Prostate tumor heterogeneity is a major factor in disease management. Heterogeneity could be due to multiple cancer cell types with distinct gene expression. Of clinical importance is the so-called cancer stem cell type. Cell type-specific transcriptomes are used to examine lineage relationship among cancer cell types and their expression similarity to normal cell types including stem/progenitor...
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