Article
Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies.
BMC genetics - 16 Jun 2009
Hao Ke, Chudin Eugene, McElwee Joshua, Schadt Eric E
Abstract excerpt
BACKGROUND: Although high-throughput genotyping arrays have made whole-genome association studies (WGAS) feasible, only a small proportion of SNPs in the human genome are actually surveyed in such studies. In addition, various SNP arrays assay different sets of SNPs, which leads to challenges in comparing results and merging data for meta-analyses. Genome-wide imputation of untyped markers allows us to address...
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