Article
SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.
Oncogene - 9 Jun 2016
Barbáchano A, Fernández-Barral A, Pereira F, Segura M F, Ordóñez-Morán P, Carrillo-de Santa Pau E, González-Sancho J M, Hanniford D, Martínez N, Costales-Carrera A, Real F X, Pálmer H G, Rojas J M, Hernando E, Muñoz A
Abstract excerpt
SPROUTY-2 (SPRY2) is a modulator of tyrosine kinase receptor signaling with receptor- and cell type-dependent inhibitory or enhancing effects. Studies on the action of SPRY2 in major cancers are conflicting and its role remains unclear. Here we have dissected SPRY2 action in human colon cancer. Global transcriptomic analyses show that SPRY2 downregulates genes encoding tight junction proteins such as claudin-7...
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