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Article

Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial–mesenchymal transition

5 Oct 2015

Abstract excerpt

Sprouty (SPRY) appears to act as a tumor suppressor in cancer, whereas we demonstrated that SPRY2 functions as a putative oncogene in colorectal cancer (CRC) (Oncogene, 2010, 29: 5241-5253). We investigated the mechanisms by which SPRY regulates epithelial-mesenchymal transition (EMT) in CRC. SPRY1 and SPRY2 mRNA transcripts were significantly upregulated in human CRC. Suppression of SPRY2 repressed AKT2 and...

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PMID: 26434583
DOI: 10.1038/onc.2015.365

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