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Long noncoding RNA <i>SPRY4-IT1</i> regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins

18 Dec 2015

Abstract excerpt

Epithelial cells line the intestinal mucosa and form an important barrier to a wide array of noxious substances in the lumen. Disruption of the barrier integrity occurs commonly in various pathologies. Long noncoding RNAs (lncRNAs) control diverse biological processes, but little is known about the role of lncRNAs in regulation of the gut permeability. Here we show that the lncRNA SPRY4-IT1 regulates the...

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PMID: 26680741
DOI: 10.1091/mbc.e15-10-0703

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