Metastatic Malignant Melanoma With Complete Loss of Differentiation Markers (Undifferentiated/Dedifferentiated Melanoma): Analysis of 14 Patients Emphasizing Phenotypic Plasticity and the Value of Molecular Testing as Surrogate Diagnostic Marker.

doi:10.1097/PAS.0000000000000527

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Metastatic Malignant Melanoma With Complete Loss of Differentiation Markers (Undifferentiated/Dedifferentiated Melanoma): Analysis of 14 Patients Emphasizing Phenotypic Plasticity and the Value of Molecular Testing as Surrogate Diagnostic Marker.

The American journal of surgical pathology - 1 Feb 2016

Agaimy Abbas, Specht Katja, Stoehr Robert, Lorey Thomas, Märkl Bruno, Niedobitek Gerald, Straub Melanie, Hager Thomas, Reis Anna-Carinna, Schilling Bastian, Schneider-Stock Regine, Hartmann Arndt, Mentzel Thomas

Abstract excerpt

Metastatic malignant melanoma is notorious for its phenotypic diversity and loss of differentiation markers. We herein summarized our experience with 14 metastatic melanomas showing complete loss of immunohistochemical melanocytic markers (with or without heterologous differentiation). Patients included 11 men and 3 women aged 24 to 78 years (median, 67 y). Thirteen patients had histologically confirmed primary...

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PMID: 26448190
DOI: 10.1097/PAS.0000000000000527

Genes

BRAF
NRAS
CDK4
MDM2
SMARCB1
SOX10

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