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Article

A Comparative Genomic Study of Conventional and Undifferentiated Melanoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2024

Fischer Grant M, Mahadevan Navin R, Hornick Jason L, Fletcher Christopher D M, Russell-Goldman Eleanor

Abstract excerpt

Undifferentiated melanoma, defined as melanoma that has lost all usual phenotypic and immunohistochemical characteristics of conventional melanoma, can pose significant diagnostic challenges. Molecular studies have advanced our understanding of undifferentiated melanoma by demonstrating that a subset of these tumors harbors known melanoma driver alterations in genes such as BRAF, NRAS, and NF1. However, there is...

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Source

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Identifiers

PMID: 39332711
DOI: 10.1016/j.modpat.2024.100626
PMCID: PMC12320567

Genes

NRAS
RAC1
BRAF
NF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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