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Article

A Primary Dedifferentiated Melanoma, Masquerading as a Soft Tissue Sarcoma, Displaying BRAF p.V600E, CDKN2A, TP53, and TERT Promoter Mutations.

International journal of surgical pathology - 1 Sept 2026

Rekhi Bharat, Bapat Prachi, Agaimy Abbas, Ramadwar Mukta, Shetty Omshree

Abstract excerpt

Primary dedifferentiated and undifferentiated melanomas are extremely rare and diagnostically challenging. A 55-year-old female patient referred to us with a slowly growing mass in her right popliteal region of 1 year duration, which, on biopsy, performed elsewhere, was diagnosed as a synovial sarcoma. Radio imaging revealed a 6.9-cm-sized intense lesion in the dermis. A review of the biopsy and a subsequent...

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Topics

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Share to Cyclin-Dependent Kinase Inhibitor p16
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 42024101
DOI: 10.1177/10668969261437722

Genes

BRAF
CDKN2A
TERT
TP53
MIB1
PRAME
SOX10

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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