Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response.

doi:10.1016/j.modpat.2023.100165

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2023

Kasago Israel S, Chatila Walid K, Lezcano Cecilia M, Febres-Aldana Christopher A, Schultz Nikolaus, Vanderbilt Chad, Dogan Snjezana, Bartlett Edmund K, D'Angelo Sandra P, Tap William D, Singer Samuel, Ladanyi Marc, Shoushtari Alexander N, Busam Klaus J, Hameed Meera

Abstract excerpt

The distinction between undifferentiated melanoma (UM) or dedifferentiated melanoma (DM) from undifferentiated or unclassifiable sarcoma can be difficult and requires the careful correlation of clinical, pathologic, and genomic findings. In this study, we examined the utility of mutational signatures to identify patients with UM/DM with particular attention as to whether this distinction matters for treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Checkpoint Inhibitors

Share to Immunotherapy

Share to Melanoma

Share to Melanoma, Cutaneous Malignant

Share to Neoplasms, Second Primary

Share to Sarcoma

Share to Soft Tissue Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 36990277
DOI: 10.1016/j.modpat.2023.100165
PMCID: PMC10698871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response.PMID 36990277Read ↗

Comprehensive molecular profile of primary cutaneous epithelioid rhabdomyosarcoma: A tumor genomically and molecularly related to malignant melanomaSemantic proximity Read ↗

Metastatic Malignant Melanoma With Complete Loss of Differentiation Markers (Undifferentiated/Dedifferentiated Melanoma): Analysis of 14 Patients Emphasizing Phenotypic Plasticity and the Value of Molecular Testing as Surrogate Diagnostic Marker.Semantic proximity Read ↗

A Comparative Genomic Study of Conventional and Undifferentiated Melanoma.Semantic proximity Read ↗

Multidisciplinary Care for Melanoma of Unknown Primary: Experience in the Era of Molecular Profiling.Semantic proximity Read ↗

Cutaneous Epithelioid/Pleomorphic Rhabdomyosarcoma, Melanoma in Disguise? An Immunohistochemical, Molecular, and Epigenetic Study of 13 Patients.Semantic proximity Read ↗

Dedifferentiated and undifferentiated melanomas: a practical approach to a challenging diagnosisSemantic proximity Read ↗

CD10 and p63 expression in a sarcomatoid undifferentiated melanoma: A cautionary (and molecularly annotated) tale.Semantic proximity Read ↗

A Primary Dedifferentiated Melanoma, Masquerading as a Soft Tissue Sarcoma, Displaying BRAF p.V600E, CDKN2A, TP53, and TERT Promoter Mutations.Semantic proximity Read ↗

Multi-Platform Omics Analysis for Identification of Molecular Characteristics and Therapeutic Targets of Uveal Melanoma.Semantic proximity Read ↗

Primary de-differentiated, trans-differentiated and undifferentiated melanomas: overview of the clinicopathological, immunohistochemical and molecular spectrum.Semantic proximity Read ↗

Landscape of mutations in early stage primary cutaneous melanoma: An InterMEL study.Semantic proximity Read ↗

The utility of DNA methylation profiling in the diagnosis of un‐, de‐ and trans‐differentiated melanoma: a series of 11 casesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.