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Article

The utility of DNA methylation profiling in the diagnosis of un‐, de‐ and trans‐differentiated melanoma: a series of 11 cases

2 Sept 2024

Abstract excerpt

AIMS: Melanomas are recognised for their remarkable morphological plasticity. Some tumours may lose conventional features and/or acquire non-melanocytic characteristics, referred to as undifferentiated, dedifferentiated and transdifferentiated melanoma. Despite this phenotypical variability, melanomas typically maintain their cancer driver aberrations, affecting genes such as BRAF, NRAS and NF1. Currently, little...

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PMID: 39223066
DOI: 10.1111/his.15309

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