Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption.

doi:10.1093/alcalc/agv114

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Article

Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 May 2016

Celorrio David, Muñoz Xavier, Amiano Pilar, Dorronsoro Miren, Bujanda Luis, Sánchez María-José, Molina-Montes Esther, Navarro Carmen, Chirlaque M Dolores, MaríaHuerta José, Ardanaz Eva, Barricarte Aurelio, Rodriguez Laudina, Duell Eric J, Hijona Elizabeth, Herreros-Villanueva Marta, Sala Núria, Alfonso-Sánchez Miguel A, de Pancorbo Marian M

Abstract excerpt

AIMS: To examine the role of genetic and environmental factors in the pathogenesis of alcohol dependence in a Spanish cohort of women and men. METHODS: We analyzed the relationship between 56 genetic variants in 7 genes associated with the dopaminergic reward pathway and excessive alcohol consumption. The study sample (N = 1533, of which 746 were women) consisted of 653 heavy consumers and 880 very low consumers...

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Identifiers

PMID: 26447226
DOI: 10.1093/alcalc/agv114

Genes

DRD2
MAOA
COMT
DRD1
DRD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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