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Article

An Alu‐like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells

25 Jun 2010

Abstract excerpt

ABSTRACT Neuroblastoma (NB) is a pediatric cancer characterized by remarkable cell heterogeneity within the tumor nodules. Here, we demonstrate that the synthesis of a pol III‐transcribed noncoding (nc) RNA (NDM29) strongly restricts NB development by promoting cell differentiation, a drop of malignancy processes, and a dramatic reduction of the tumor initiating cell (TIC) fraction in the NB cell population....

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PMID: 20581224
DOI: 10.1096/fj.10-157032

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