Article
Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas.
Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013
Ikegaki Naohiko, Shimada Hiroyuki, Fox Autumn M, Regan Paul L, Jacobs Joshua R, Hicks Sakeenah L, Rappaport Eric F, Tang Xao X
Abstract excerpt
Cancer stem cells (CSCs) are plastic in nature, a characteristic that hampers cancer therapeutics. Neuroblastoma (NB) is a pediatric tumor of neural crest origin, and half of the cases are highly aggressive. By treating NB cell lines [SKNAS, SKNBE(2)C, CHP134, and SY5Y] with epigenetic modifiers for a short time, followed by sphere-forming culture conditions, we have established stem cell-like NB cells that are...
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