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Article

LMNA Knock-Down Affects Differentiation and Progression of Human Neuroblastoma Cells

26 Sept 2012

Abstract excerpt

BACKGROUND: Neuroblastoma (NB) is one of the most aggressive tumors that occur in childhood. Although genes, such as MYCN, have been shown to be involved in the aggressiveness of the disease, the identification of new biological markers is still desirable. The induction of differentiation is one of the strategies used in the treatment of neuroblastoma. A-type lamins are components of the nuclear lamina and are...

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PMID: 23049808
DOI: 10.1371/journal.pone.0045513

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