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Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis

6 Oct 2015

Abstract excerpt

OBJECTIVES: It has been suggested that the lysosomal recycling process called macro-autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate the autophagy-indispensable Atg5 gene specifically in chondrocytes and analyse the development of osteoarthritis upon aging and in a post-traumatic model. METHODS: Mice lacking the Atg5 gene in their chondrocytes (Atg5cKO) were generated by...

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PMID: 26438374
DOI: 10.1136/annrheumdis-2015-207742

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