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Article

Toll-IL1 receptor-mediated innate immune responses vary across HBV genotype and predict treatment response to pegylated-IFN in HBeAg-positive CHB patients.

Journal of viral hepatitis - 1 Mar 2016

Visvanathan K, Lang T, Ryan K, Wilson R, Skinner N A, Thompson A J V, Ahn S H, Weilert F, Abbott W, Gane E, Colledge D, Li K, Locarnini S, Mansell A, Revill P A

Abstract excerpt

Patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) have suppressed TLR2 expression, function and cytokine production. The aim of this study was to explore the importance of hepatitis B virus (HBV) genotype in innate immune responses and investigate whether Toll-like receptor (TLR) expression/function has potential roles as predictive biomarkers of successful therapy with pegylated...

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Share to Hepatitis B, Chronic
Share to Hepatitis B e Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Interferon-alpha

Share to Interleukin-6

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Share to Receptors, Interleukin-1

Share to Toll-Like Receptor 2

Source

Identifiers

PMID: 26436722
DOI: 10.1111/jvh.12477

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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