Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jul 2014

Kurian Allison W, Hare Emily E, Mills Meredith A, Kingham Kerry E, McPherson Lisa, Whittemore Alice S, McGuire Valerie, Ladabaum Uri, Kobayashi Yuya, Lincoln Stephen E, Cargill Michele, Ford James M

Abstract excerpt

PURPOSE: Multiple-gene sequencing is entering practice, but its clinical value is unknown. We evaluated the performance of a customized germline-DNA sequencing panel for cancer-risk assessment in a representative clinical sample. METHODS: Patients referred for clinical BRCA1/2 testing from 2002 to 2012 were invited to donate a research blood sample. Samples were frozen at -80° C, and DNA was extracted from them...

Topics

Join the communities discussing this publication.

BRCA1 Protein
BRCA2 Protein
Early Detection of Cancer
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

Risk Assessment

Risk Reduction Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 24733792
DOI: 10.1200/JCO.2013.53.6607
PMCID: PMC4067941

Genes

BRCA1
ATM
BLM
CDH1
MLH1
MUTYH
NBN
PRSS1
SLX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment.PMID 24733792Read ↗

Detection of Germline Mutations in Breast Cancer Patients with Clinical Features of Hereditary Cancer Syndrome Using a Multi-Gene Panel Test.Semantic proximity Read ↗

Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.Semantic proximity Read ↗

Next-generation sequencing for hereditary breast and gynecologic cancer risk assessment.Semantic proximity Read ↗

The Clinical Utility of Next Generation Sequencing Results in a Community-Based Hereditary Cancer Risk Program.Semantic proximity Read ↗

The Clinical and Genetic Landscape of Hereditary Cancer: Experience from a Single Clinical Diagnostic Laboratory.Semantic proximity Read ↗

Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing.Semantic proximity Read ↗

The Perils of Single-Site Genetic Testing for Hereditary Cancer Syndromes in the Era of Next-Generation Sequencing.Semantic proximity Read ↗

Clinical testing with a panel of 25 genes associated with increased cancer risk results in a significant increase in clinically significant findings across a broad range of cancer histories.Semantic proximity Read ↗

Development and Validation of a 34-Gene Inherited Cancer Predisposition Panel Using Next-Generation Sequencing.Semantic proximity Read ↗

Next-generation universal hereditary cancer screening: implementation of an automated hereditary cancer screening program for patients with advanced cancer undergoing tumor sequencing in a large HMO.Semantic proximity Read ↗

Detection of Germline Mutations in a Cohort of 250 Relatives of Mutation Carriers in Multigene Panel: Impact of Pathogenic Variants in Other Genes beyond <em>BRCA1/2</em>Semantic proximity Read ↗

Consideration for Multigene Panel Testing Outside of Cancer-Specific Genetic Testing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.